Transcriptional control of central T cell tolerance by NR4A family nuclear receptors
H. V. Nielsen, J. L. Mueller, R. Hiwa, L. Yang, I. Proekt, E. Rackaityte, D. Aylard, C. D. Scharer, M. Anderson, B. B. Au-Yeung, J. Zikherman
This study identifies the role of Nr4a family nuclear receptors in transcriptional control of T cell tolerance during thymic development, showing their necessity for negative selection and anergy-like programs in self-reactive T cells.
bioRxiv · May 19, 2024 · PreprintImmunology