D. Aran

Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor Therapy

The paper maps treatment-associated changes in the tumor immune microenvironment using single-cell RNA sequencing and identifies transition patterns that predict response to checkpoint inhibitor therapy.

EpiSort: Enumeration of cell types using targeted bisulfite sequencing

EpiSort uses targeted bisulfite sequencing to accurately enumerate 23 cell types in tumors, offering a new approach for cancer microenvironment analysis.

CD161 mediates prenatal immune suppression of IFNγ-producing PLZF+ T cells

The paper identifies CD161-mediated suppression of IFNγ-producing PLZF+ T cells in the human fetal intestine, highlighting their role in prenatal immune regulation.

Reference-based annotation of single-cell transcriptomes identifies a profibrotic macrophage niche after tissue injury

The paper uses scRNA-seq to identify a profibrotic macrophage subtype in injured lung tissue, showing its role in fibrosis and potential as a therapeutic target.