D. Yu

IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection

This study shows IL-2 enhances CD8+ T cell effector function but inhibits CXCR5+ TPEX cell formation and follicular infection control in chronic LCMV infection.

LXA4 promotes the browning of white adipose through miR-133a-3p/SIRT1 pathway

This study shows LXA4 promotes white adipose browning and improves insulin resistance via the miR-133a-3p/SIRT1 pathway in mice.

Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2

This study identifies BTN3A2 as a primate-specific gene that inhibits SARS-CoV-2 infection by reducing ACE2 expression and blocking viral attachment.

A new story of four Hexapoda classes: Protura as the sister to all other hexapods

This study resolves the phylogenetic relationships of early hexapods, finding Protura as the earliest-diverging lineage and supporting a new classification of hexapod evolution.

Nanotopography boosts cellular uptake by inducing macropinocytosis

This study shows that nanoporous surfaces enhance cellular uptake of genetic material and other molecules by inducing macropinocytosis, with optimal pore size of 400 nm.

Thermo-optoplasmonic single-molecule sensing on optical microcavities

This paper demonstrates thermo-optoplasmonic sensing using optoplasmonic microcavities to detect single-molecule absorption, validating the technique with seven molecules and proposing a model for single-molecule absorption spectrometers.

Successful spread of mcr-1-bearing IncX4 plasmids is associated with variant in replication protein of IncX4 plasmids

The paper shows that IncX4 plasmids with pir-1 have higher mcr-1 expression and fitness burden but lower invasion rates compared to pir-2 plasmids, explaining why mcr-1 is absent from pir-2 plasmids.

MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality

This study shows that LXY18 selectively kills MYC-overexpressing cancer cells by inducing mitotic arrest, offering a new approach to target MYC-driven tumors.

Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice

This study evaluates a multivalent mRNA vaccine against SARS-CoV-2 variants in mice, showing broad protection against multiple strains.

Single-cell impedance cytometry of anticancer drug-treated tumor cells exhibiting mitotic arrest state to apoptosis using low-cost silver-PDMS microelectrodes

This study uses microfluidic impedance cytometry to analyze the cellular state changes in Hela cells treated with paclitaxel and vinblastine, showing distinct electrical parameter shifts during mitotic arrest and apoptosis.

MFSD7c functions as a transporter of choline at the blood-brain barrier

This study identifies MFSD7c as a choline transporter at the blood-brain barrier and links its dysfunction to Fowler syndrome.

Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity

This study shows that deleting specific mitochondrial Complex I subunits, Ndufs4 and Ndufs6, enhances tumor immunogenicity and sensitivity to immune checkpoint blockade in mouse melanoma models.

Deep learning enables accurate soft tissue deformation estimation in vivo

This paper introduces StrainNet, a deep learning model that accurately estimates in vivo tissue deformation, outperforming traditional methods by nearly 90%.

Cryo-EM structure of TMEM63C suggests it functions as a monomer

The paper determines the cryo-EM structure of mouse TMEM63C, reveals structural differences from plant orthologues, and shows TMEM63C functions as a monomer while TMEM63B is a mix of monomer and dimer.

22kHz Ultrasonic Vocalizations and Body Freezing May Represent Two Systems of Fear in Rodent Fear Conditioning Paradigms

This study investigates two fear responses in rodents, finding that 22kHz ultrasonic vocalizations reflect subjective fear while body freezing indicates an automatic defensive response.

Structural polymorphisms within a common powdery mildew effector scaffold as a driver of co-evolution with cereal immune receptors

This study reports the structures of powdery mildew effector proteins and shows how structural polymorphisms within a common scaffold drive co-evolution with cereal immune receptors.

Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis development

This study identifies RCAN1+IL1+ senescent synovial fibroblasts as drivers of osteoarthritis by secreting saturated fatty acids, and shows that targeting RCAN1 reduces OA progression in mice.

Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities

This paper validates a murine proteome-wide PhIP-seq library to identify autoantibody specificities in autoimmune disease models.

An RNA to rule them all: Critical steps in Lassa virus ribonucleoparticle assembly and recruitment

This study identifies RNA's role in disassembling NP trimers and forming RNA-bound assemblies, and shows Z protein interaction with NP is pH-dependent.

A unified classification system for HIV-1 5' long terminal repeats

This paper establishes a unified classification system for HIV-1 5' LTRs using public database sequences, revealing recombination events that alter transcription factor binding sites in 6 out of 22 tested strains.

Frame Editors for Precise, Template-Free Frameshifting

This paper introduces Frame Editors (FEs) that improve CRISPR-Cas9 editing accuracy by inducing controlled frameshifts without templates, reducing random mutations and off-target effects.

Disruption of OsLAT5 is sufficient to endow rice tolerance to dihydropyridine herbicides at commercial application concentrations

This study shows that disrupting OsLAT5 in rice confers tolerance to dihydropyridine herbicides without affecting yield or grain quality.

Molecular Mechanism for Bacterial Degradation of Plant Hormone Auxin

This study identifies AdgB and AdgI as key proteins in the Variovorax auxin-degradation operon, revealing their roles in IAA uptake and conversion to oxIAA, and demonstrates the operon's potential for IAA regulation in E. coli.

Type 17 Follicular Helper T (Tfh17) Cells are Superior for Memory Maintenance

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

Dissecting the genetic basis of the heterosis of Y900, an elite super-hybrid rice

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

Contrasting roles of landscape compositions in shaping functional traits of arthropod community in subtropical vegetable fields

The paper evaluates how different habitat compositions affect functional traits of arthropod communities in subtropical vegetable fields, finding that forest and grassland habitats enhance functional diversity while non-brassica plantations and water bodies reduce it.

Disruption of CFAP418 interaction with lipids causes abnormal membrane-associated cellular processes in retinal degenerations

This study identifies CFAP418's role in lipid binding and membrane processes, showing that its disruption causes lipid imbalance and mitochondrial defects in retinal degenerations.

TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

Regulation of metabolic health by dietary histidine in mice

This study shows that reducing dietary histidine improves metabolic health and body composition in mice and explains BMI differences in humans.

Gαq modulates the energy metabolism of osteoclasts

This study shows that Gαq enhances osteoclast energy metabolism by promoting glycolysis and mitochondrial respiration, contributing to increased bone resorption.