Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
E. Zlamalova, C. Rodger, F. Greco, J. Kleniuk, A. G. Nadadur, Z. Kadlecova, E. Reid
This study shows that atlastin-1 deficiency in human cortical neurons disrupts ER morphology, endosomal tubulation, and lysosomal proteolysis, linking ER dysfunction to HSP pathogenesis.
bioRxiv · Feb 29, 2024Cell Biology