D. Edmison

Axonal organelle buildup from loss of AP-4 complex function causes exacerbation of amyloid plaque pathology and gliosis in Alzheimers disease mouse model

The paper shows that loss of AP-4 complex function causes axonal lysosome buildup, which worsens amyloid plaque pathology and gliosis in an Alzheimer's disease mouse model.

AP-4 regulates neuronal lysosome composition, function and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi network

This study shows AP-4 regulates neuronal lysosome composition, function, and transport by controlling the export of lysosomal receptors from the trans-Golgi network.