S. Gowrishankar

Axonal organelle buildup from loss of AP-4 complex function causes exacerbation of amyloid plaque pathology and gliosis in Alzheimers disease mouse model

The paper shows that loss of AP-4 complex function causes axonal lysosome buildup, which worsens amyloid plaque pathology and gliosis in an Alzheimer's disease mouse model.

Identification of novel oncogenic transcriptional targets of mutant p53 in Esophageal Squamous Cell Carcinoma

This study identifies novel oncogenic targets of rare non-hotspot p53 mutations in ESCC and validates their functional roles in tumorigenesis.

AP-4 regulates neuronal lysosome composition, function and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi network

This study shows AP-4 regulates neuronal lysosome composition, function, and transport by controlling the export of lysosomal receptors from the trans-Golgi network.

JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton

This study shows that JIP3 depletion disrupts axonal cytoskeleton organization and causes lysosome accumulations in human neurons, linking lysosome transport to cytoskeletal regulation.

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

This study investigates the roles of JIP3 and JIP4 in axonal lysosome transport using human iPSC-derived neurons, showing their involvement in preventing lysosome accumulation and amyloid-beta production.

Cytoplasm localized ARID1B promotes oncogenesis in pancreatic cancer by activating RAF-ERK signaling

This study shows that cytoplasmic ARID1B promotes pancreatic cancer by activating RAF-ERK signaling and β-catenin transcription.