From head to tail - Atomistic mechanism of long-range coupling from the cytosolic sensor domain to the selectivity filter in TREK K2P channels
B. Tuerkaydin, M. Schewe, E. Riel, F. Schulz, J. Biedermann, T. Baukrowitz, H. Sun
The paper reveals the atomistic mechanism of long-range coupling between the cytosolic sensor domain and the selectivity filter in TREK K2P channels, showing how conformational changes and phosphorylation regulate channel activity.
bioRxiv · Oct 6, 2023Biophysics