BiophysicsbioRxiv
From head to tail - Atomistic mechanism of long-range coupling from the cytosolic sensor domain to the selectivity filter in TREK K2P channels
B. Tuerkaydin, M. Schewe, E. Riel…·H. Sun
The paper reveals the atomistic mechanism of long-range coupling between the cytosolic sensor domain and the selectivity filter in TREK K2P channels, showing how conformational changes and phosphorylation regulate channel activity.
DOI 10.1038/s41467-024-48823-y