Author

M. Schewe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Assay:electrophysiology· 4 Research Focus:protein folding & dynamics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

T. Baukrowitz· 7 shared S. J. Tucker· 4 shared P. Proks· 3 shared B. C. Juers· 2 shared B. Eymsh· 2 shared E. B. Riel· 2 shared E. P. Carpenter· 2 shared H. Sun· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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7 shared papersBiophysics

T. Baukrowitz

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7 papers

Recent·Most cited

CryoEM Structure of the human THIK-1 K2P K+ Channel Reveals a Lower 'Y-gate' Regulated by Lipids and Anaesthetics

K. E. Rodstrom, B. Eymsh, P. Proks, M. S. Hayre, C. Madry, A. Rowland, S. Newstead, T. Baukrowitz, M. Schewe, S. J. Tucker

The paper presents a cryoEM structure of the human THIK-1 K2P K+ channel, revealing structural features and regulatory mechanisms involving lipids and anaesthetics.

bioRxiv · Jun 26, 2024 · PreprintBiophysics

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2

L. C. Neelsen, E. B. Riel, S. Rinne, F.-R. Schmid, B. C. Juers, M. Bedoya, J. P. Langer, B. Eymsh, A. K. Kiper, S. Cordeiro, N. Decher, T. Baukrowitz, M. Schewe

This paper identifies a lower cytoplasmic gate in TALK-2 channels and demonstrates bidirectional coupling between this gate and the selectivity filter gate, showing that ion occupancy and stimuli can influence both gates.

bioRxiv · Nov 22, 2023Biophysics

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation

K. E. J. Rodstrom, A. Cloake, J. Sormann, A. Baronina, K. H. M. Smith, A. C. W. Pike, J. Ang, P. Proks, M. Schewe, I. Holland-Kaye, S. R. Bushell, J. Elliott, E. Pardon, T. Baukrowitz, R. J. Owens, , S. J. Tucker

The paper identifies nanobodies that selectively modulate TREK-2 channel activity and reveals their binding mechanisms through structural analysis.

bioRxiv · Oct 19, 2023Biophysics

From head to tail - Atomistic mechanism of long-range coupling from the cytosolic sensor domain to the selectivity filter in TREK K2P channels

B. Tuerkaydin, M. Schewe, E. Riel, F. Schulz, J. Biedermann, T. Baukrowitz, H. Sun

The paper reveals the atomistic mechanism of long-range coupling between the cytosolic sensor domain and the selectivity filter in TREK K2P channels, showing how conformational changes and phosphorylation regulate channel activity.

bioRxiv · Oct 6, 2023Biophysics

The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide (PIP2) and fatty acid metabolism (LC-CoA)

E. B. Riel, B. C. Juers, S. Cordeiro, M. A. Musinszki, M. Schewe, T. Baukrowitz

This study investigates the regulation of K2P channels by polyanionic lipids PIP2 and LC-CoA, revealing activation and inhibition effects across subfamilies.

bioRxiv · Jul 1, 2021Biophysics

Multiple Mechanisms Underlie State-Independent Inhibitory Effects of Norfluoxetine on TREK-2 K2P Channels

P. Proks, M. Schewe, L. J. Conrad, S. Rao, K. Rathje, K. E. Rodstrom, E. P. Carpenter, T. Baukrowitz, S. J. Tucker

This study identifies multiple mechanisms by which norfluoxetine inhibits TREK-2 K2P channels, showing state-independent effects and interactions with filter stability and voltage-dependent gating.

bioRxiv · Oct 29, 2020Biophysics

Selectivity Filter Instability Dominates the Low Intrinsic Activity of the TWIK-1 K2P K+ Channel

E. Nematian-Ardestani, M. F. Abd-Wahab, F. C. Chatelain, H. Sun, M. Schewe, T. Baukrowitz, S. J. Tucker

This study identifies the instability of the selectivity filter (SF) gate in TWIK-1 K2P channels as the primary cause of their low intrinsic activity.

bioRxiv · Dec 2, 2019Biophysics