Advancing CAR T-Cell Therapy: Simultaneously Attack Tumor and Immunosuppressive Cells in the Tumor Microenvironment
Y. Luo, E. S. Garavito, M. M. Brooks, M. E. Gadd, Y. Qie, M. J. U. Navas, T. Hundal, S. Li, A. O. Lopez, V. K. Jones, Y. Lou, T. Patel, R. Dronca, M. A. Kharfan-Dabaja, H. Dong, , H. Qin
This paper develops a PD-L1-targeting CAR T-cell therapy (MC9999) that effectively attacks both tumor and immunosuppressive cells in solid tumors.
bioRxiv · Mar 25, 2024 · PreprintCancer Biology