H. Dong

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

Advancing CAR T-Cell Therapy: Simultaneously Attack Tumor and Immunosuppressive Cells in the Tumor Microenvironment

This paper develops a PD-L1-targeting CAR T-cell therapy (MC9999) that effectively attacks both tumor and immunosuppressive cells in solid tumors.

YAP promotes chromosomal instability by transcriptionally activating AJUBA through its super enhancer in breast cancer

This study identifies YAP's role in promoting chromosomal instability in breast cancer by activating AJUBA through its super enhancer, leading to AURKA activation and aberrant mitosis.

Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

This study shows that inhibiting OGT activates type I interferon-dependent antitumor immunity by enhancing the cGAS-STING pathway through genomic instability.

A soybean rust effector protease suppresses host immunity and cleaves a 3-deoxy-7-phosphoheptulonate synthase

This study identifies PpEC15, a soybean rust effector protease, which suppresses host immunity by cleaving a 3-deoxy-7-phosphoheptulonate synthase and modulating immune signaling pathways.

High red/far-red ratio promotes root colonization of Serratia plymuthica A21-4 in tomato by root exudates-stimulated chemotaxis and biofilm formation

The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

This study identifies apicoplast transporters in Toxoplasma gondii using TurboID and genome engineering, showing AMT1 and AMT2 are critical for parasite growth and virulence.

Effect of Aging, Sex, and Gene (Fbln5) on Arterial Stiffness of Mice: 20 Weeks Adult Fbln5-knockout Mice Have Older Arteries than 100 Weeks Wild-Type Mice

This study shows that Fbln5 gene knockout in mice significantly increases arterial stiffness, equivalent to aging 51 years in humans, and introduces a new UFD model for more accurate biomechanical analysis.

Noncanonical TRAIL Signaling Promotes Myeloid-Derived Suppressor Cell Abundance and Tumor Progression in Cholangiocarcinoma

This study shows that TRAIL+ cancer cells use noncanonical TRAIL signaling in MDSCs to promote their abundance and tumor progression in cholangiocarcinoma.

Plant diversity stabilizes soil temperature

This study shows plant diversity stabilizes soil temperature by increasing organic carbon and leaf area index, with effects strengthening over time and under extreme conditions.

Label-free quantitative proteomics analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

Resilient CD8+ T cells maintain a high cytotoxic capacity by balancing ROS via ME1 upregulation

This paper identifies CX3CR1+ CD8+ T cells with low mitochondrial membrane potential as functionally resilient, showing high cytotoxicity and reduced ROS through ME1 upregulation, which enhances their anti-tumor activity.

Effect of Nonlinear Hyperelastic Property of Arterial Tissues on the Pulse Wave Velocity based on the Unified-Fiber-Distribution (UFD) Model

This study investigates how nonlinear hyperelastic properties of arterial tissue affect pulse wave velocity using a unified-fiber-distribution model, showing increased PWV with higher circumferential fiber content and non-monotonic dependencies on fiber and matrix stiffness.

Discovery of a novel monoclonal PD-L1 antibody H1A that promotes T-cell mediated tumor killing activity in renal cell carcinoma

This study identifies a novel monoclonal PD-L1 antibody H1A that enhances T-cell mediated tumor killing in renal cell carcinoma compared to existing PD-1/PD-L1 inhibitors.

Macrophage migrates on alternate non-adhesive surfaces

This study shows macrophages can migrate across non-adhesive PEG surfaces by adopting a mesenchymal mode, overcoming the limitations seen in other cell types.

Potent Bacterial Vaccines Require FcγRIIB-mediated Pathogen Capture by Liver Sinusoidal Endothelium

This paper identifies FcγRIIB-mediated capture of antibody-coated bacteria by liver sinusoidal endothelial cells as a mechanism for superior vaccine efficacy.

The integrated LIM-peptidase domain of the CSA1/CHS3 paired immune receptor detects changes in DA1 family peptidase inhibitors to confer Albugo candida resistance in Arabidopsis.

The paper shows that the DAR4 ID in the CSA1/CHS3 receptor detects reduced DAR3 levels caused by Albugo candida, triggering defense mechanisms in Arabidopsis.

Single cell RNA sequencing reveals mechanisms underlying a senescence-like phenotype of Alveolar Macrophages during Aging

This study uses single-cell RNA sequencing to show that aged alveolar macrophages exhibit a senescence-like phenotype linked to reduced CBFβ expression and impaired self-renewal.

Modulation of Receptor-like Trans-Membrane Kinase 1 nuclear localisation by DA1 peptidases in Arabidopsis.

This study shows that DA1 peptidases cleave TMK1, releasing its kinase domain to the nucleus where it represses auxin-responsive cell growth during apical hook formation in Arabidopsis.

m6A RNA methylation impairs gene expression variability and reproductive thermotolerance in Arabidopsis

This study shows that m6A RNA methylation reduces gene expression variability and impairs reproductive thermotolerance in Arabidopsis under heat stress.

Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses

Unadjuvanted intranasal spike vaccine booster generates broad sarbecovirus protective mucosal immunity in a preclinical model.

Secreted ORF8 is a pathogenic cause of severe Covid-19 and potentially targetable with select NLRP3 inhibitors

This study identifies ORF8 as a secreted glycoprotein that drives severe COVID-19 through NLRP3 inflammasome activation and shows it is inhibited by MCC950.

Inhibition of SAR S-CoV-2 infection and replication by lactoferrin, MUC1 and α-lactalbumin identified in human breastmilk

This study identifies lactoferrin, MUC1, and α-lactalbumin in human breastmilk as antiviral components that inhibit SARS-CoV-2 infection and replication, including variants.

BMSC-Derived Exosomal MiRNAs Can Modulate Bone Restoration in Diabetic Rats with Femoral Defects

This study shows that exosomal miR-140-3p from diabetic BMSCs promotes bone restoration in diabetic rats by enhancing osteogenesis and inhibiting the plexin B1 signaling pathway.

Engineering site-selective incorporation of fluorine into natural product analogs

This paper describes engineering a fluorine-selective enzyme to produce fluorinated polyketide analogs using E. coli.

Selection and evaluation of qPCR reference genes for expression analysis in the tiny egg parasitoid wasp, Trichogramma dendrolimi Matsumura (Hymenoptera: Trichogrammatidae)

This study identifies suitable reference genes for qPCR in Trichogramma dendrolimi across developmental stages, tissues, sex, and temperature conditions.

The tetrameric assembly of 2-aminomuconic acid dehydrogenase is a functional requirement of cofactor NAD+ binding

This paper identifies the tetrameric assembly of AmnC as essential for NAD+ binding and enzymatic activity in 2-aminophenol metabolism.

A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice

This study shows that SLR14, a RIG-I agonist, prevents and treats SARS-CoV-2 infection in mice, including chronic cases and variants, through IFN-I responses.

ESD1 Affects Seed Setting Rate in Rice by Controlling Embryo Sac Development

This study shows ESD1 regulates seed setting rate in rice by controlling embryo sac development, as loss-of-function mutants exhibit reduced seed setting rates and abnormal embryo sac differentiation.

Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies

This study identifies the structural and molecular mechanisms of two neutralizing antibodies against FMDV, showing they disrupt virus-receptor interactions and provide prophylactic and therapeutic benefits.