Y. Lou

Advancing CAR T-Cell Therapy: Simultaneously Attack Tumor and Immunosuppressive Cells in the Tumor Microenvironment

This paper develops a PD-L1-targeting CAR T-cell therapy (MC9999) that effectively attacks both tumor and immunosuppressive cells in solid tumors.

In vitro antimicrobial mechanism of diacerein and potential to reverse MRSE resistance to β-lactams

This study investigates diacerein's antimicrobial mechanism against MRSE and shows it can reverse β-lactam resistance by affecting efflux systems and inducing cell lysis.

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1alpha axis in melanoma

This study shows TIPE promotes glycolysis and stemness in melanoma by interacting with PKM2 and activating HIF-1α through phosphorylation.

Multiscale mechanisms driving tissue rupture by invading cells

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

Curvature-induced cell rearrangements in biological tissues

This study investigates how curvature gradients and anisotropy drive apicobasal T1 transitions in epithelial tissues through competing mechanical mechanisms.

Mechanism of repression of the glycerol utilization operon in Borrelia burgdorferi

This study identifies a cis element that represses the glp operon in Borrelia burgdorferi, independent of RpoS, and shows BadR binds to this element, with binding efficiency influenced by c-di-GMP and carbohydrates.

The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins

This study shows that the Drosophila Toll pathway and specific Bomanins enhance resilience to Aspergillus mycotoxins by mitigating toxin effects rather than directly killing pathogens.

The N-terminal subunit of vitellogenin in planthopper eggs and saliva acts as a reliable elicitor that induces defenses in rice

This study shows that the N-terminal subunit of vitellogenin from planthoppers induces defense responses in rice, reducing egg hatching and attracting parasitoids.

Comparative genomic and pan-genomic characteristion of Staphylococcus epidermidis from different sources unveils the molecular basis and potential biomarkers of pathogenic strains

This study sequenced and analyzed 11 ocular trauma-sourced S. epidermidis genomes, identifying 10 potential biomarkers and revealing pathogenic strains may be independent of biofilm formation.

Mechanics defines the spatial pattern of compensatory proliferation

The paper identifies that spatial inhomogeneity in mechanotransduction via YAP drives compensatory proliferation in response to apoptosis.

Downregulation of NCL attenuates tumor formation and growth in cervical cancer by targeting the PI3K/AKT pathway

This study shows that reducing NCL in cervical cancer cells inhibits tumor growth by suppressing the PI3K/AKT pathway and promoting apoptosis.

Cooperative herbivory between two important pests of rice

This study shows that two rice pests, the brown planthopper and the rice striped stem borer, cooperate by jointly attacking rice plants, improving plant quality and reducing parasitism risk.

A Toll pathway effector protects Drosophila specifically from distinct toxins secreted by a fungus or a bacterium

This study shows that the Toll pathway effector BaraA protects Drosophila from toxins of Gram-positive bacteria and fungi without directly attacking the pathogens.

Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody libraries

Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak

This study estimates the basic reproduction number (R0) of 2019-nCoV in China during the early outbreak phase using exponential growth modeling and serial intervals from similar coronaviruses.

Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinoma

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

Effect of different forage-to-concentrate ratios on the structure of rumen bacteria and its relationship with nutrition levels and real-time methane production in sheep

This study examines how varying forage-to-concentrate ratios in sheep diets affect rumen bacterial structure, nutrient levels, and methane production, identifying key bacterial genera correlated with these factors.

Molecular dissection of early defense signaling underlying volatile-mediated defense priming and herbivore resistance in rice

This study shows that indole, a volatile compound, primes early defense signaling in rice, enhancing resistance to herbivores by upregulating key signaling components like OsMPK3 and OsWRKY70.

Evolution of natal dispersal in spatially heterogenous environments

This paper develops mathematical models to show that ideal-free dispersal strategies evolve in spatially heterogeneous environments, displacing source-sink strategies.