Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response
M. Keefe, H. Soderholm, H.-Y. Shih, T. Stevenson, K. Glaittli, D. M. Bowles, E. Scholl, S. Colby, S. Merchant, E. Hsu, J. Bonkowsky
This study shows that truncated EIF2B5 expression in zebrafish models of VWM activates the ISR and impairs motor behavior, suggesting a feed-forward mechanism in disease pathophysiology.
bioRxiv · May 5, 2020Physiology