EphrinA4/EphA4 controls blood pressure via arterial sympathetic innervation
E. SIMONNET, S. MARTIN, J. VILAR, E. ROY-VESSIERES, S. TAIB, V. MONCEAU, L. Pardanaud, N. BOUBY, A. Eichmann, J.-S. SILVESTRE, D. HENRION, I. V. BRUNET
This study shows EphrinA4 in arterial SMCs repels sympathetic axons, and its loss increases sympathetic innervation, leading to elevated blood pressure and hypertension under stress.
bioRxiv · Feb 3, 2023 · PreprintPhysiology