V. Bhandari

Theileria annulata Infection Promotes p53 suppression, Genomic Instability and DNA deaminase APOBEC3H upregulation leading to cancer-like phenotype in host cells

This study identifies somatic mutations and genomic instability in Theileria annulata-infected leukocytes, linking them to cancer-like phenotypes through ROS1, TP53 suppression, and APOBEC3H upregulation.

Redox-dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery

This study investigates how redox conditions affect the structure and function of MIF, identifying redox-sensitive sites that modulate its interaction with CD74.

Quantifying the Influence of Mutation Detection on Tumour Subclonal Reconstruction

This study evaluates subclonal reconstruction pipelines for prostate cancer, showing significant variability and biases in predicting subclonal architecture and mutation timing.

Divergent mutational processes distinguish hypoxic and normoxic tumours

This study identifies hypoxia-associated mutational processes and genomic features across 1,188 tumours from 27 cancer types, showing hypoxia increases mutational load and influences driver mutations and evolutionary trajectories.