Human IL-6 fosters long-term engraftment of patient derived disease-driving myeloma cells in immunodeficient mice
Z. S. Hasanali, A. Garfall, L. Burzenski, L. Shultz, Y. Tang, S. Kadu, N. Sheppard, D. Dopkin, D. T. Vogl, A. D. Cohen, A. J. Waxman, S. Susanibar-Adaniya, M. Carroll, E. Stadtmauer, D. M. Allman
The paper establishes NSG+hIL6 mice as a model for studying multiple myeloma by showing they support engraftment of patient-derived myeloma cells and develop disease features.
bioRxiv · Jan 21, 2024Cancer Biology