Y. Qi

The m6A Reader ECT1 Mediates Seed Germination via the DAG2-ECT1-PHYB Regulatory Cascade in Arabidopsis

This study identifies ECT1 as an m6A reader protein that promotes seed germination in Arabidopsis through a DAG2-ECT1-PHYB regulatory cascade involving transcriptional and post-transcriptional control.

Elevated CO2 alters soybean physiology and defense responses, and has disparate effects on susceptibility to diverse microbial pathogens

This study examines how elevated CO2 affects soybean susceptibility to various pathogens and finds mixed effects on disease outcomes and defense responses.

Sapling: Inferring and Summarizing Tumor Phylogenies from Bulk Data using Backbone Trees

Sapling infers and summarizes tumor phylogenies from bulk data using backbone trees, demonstrating high-quality results on simulated and real data.

Investigating the biosynthesis and roles of the auxin phenylacetic acid during Pseudomonas syringae-Arabidopsis thaliana pathogenesis

This study investigates the role of phenylacetic acid (PAA) produced by Pseudomonas syringae during infection of Arabidopsis thaliana, showing that PAA/IAA homeostasis affects plant-microbial interactions.

Critical analysis of polycyclic tetramate macrolactam biosynthetic cluster phylogeny and functional diversity

This study analyzes PTM biosynthetic clusters to uncover their phylogenetic diversity and functional complexity, revealing gaps in bioinformatics predictions and highlighting challenges in genomic discovery.

Protecting Allogeneic Pancreatic Islet Grafts by Engineered Veto

This study uses adenoviral vectors to express CD8-TCR chains in pancreatic islets, enabling them to induce immune tolerance and protect against rejection without systemic immunosuppression.

RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

This study identifies RBM7 deficiency as a driver of breast cancer metastasis through MFGE8 splicing regulation and NF-kB pathway suppression.

Small-molecule activators of a bacterial signaling pathway inhibit virulence

This study identifies small-molecule activators of the FixLJ pathway in Burkholderia that inhibit virulence without toxicity.

The role of neutrophil typing in homeostatic resilience protective model of inflammatory preconditioning

This study investigates the role of IRF4 and IRF5 in neutrophil response during septic peritonitis, showing their involvement in PMN phenotype switching and inflammatory outcomes.

Consensus Tree under the Ancestor-Descendant Distance is NP-hard

The paper proves that finding a consensus tree minimizing the total ancestor-descendant distance is NP-hard for tumor phylogenies.

Snapshots of ribosome dynamics near atomic-resolution in situ: full insight into the eukaryotic elongation cycle

The paper uses cryo-EM to analyze ribosome conformations in yeast, revealing dynamics of the eukaryotic elongation cycle with elongation factors.

African swine fever virus I196L is a virulence determinant and its deletant induces robust protection in Domestic pig

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

Molecular tuning of sea anemone stinging

The paper shows how different sea anemone species have evolved distinct voltage-gated calcium channel properties to adapt their stinging behavior to their ecological niches.

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

This study investigates chromosome loss in CRISPR-Cas9-engineered T cells and shows a modified manufacturing process reduces it while preserving editing efficacy.

Root associated bacterial communities and root metabolite composition are linked to nitrogen use efficiency in sorghum

This study links root-associated bacterial communities and root metabolite composition to nitrogen use efficiency in sorghum under different nitrogen conditions.

An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination

Difference in determinants and changing patterns of plant community composition with and without grazing across semi-arid and arid regions in Mongolian steppe

The paper examines how plant community composition changes with and without grazing in semi-arid and arid Mongolian regions, finding aridity has a significant impact regardless of grazing, but grazing eliminates soil pH effects.

On the origin and evolution of the mosquito male-determining factor Nix

This study investigates the origin and evolution of the mosquito male-determining factor Nix across Culicinae subfamily species, finding it originated 133-165 MYA and evolved faster than related factors.

cpSRP54 and FtsH cooperate thylakoid membrane associated proteostasis during de-etiolation in Arabidopsis thaliana

The paper shows cpSRP54 and FtsH work together in thylakoid membrane protein quality control during de-etiolation in Arabidopsis, and provides a trackable marker for monitoring their activities.

Born with intronless ERF transcriptional factors: C4 photosynthesis inherits a legacy dating back 450 million years

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

Analysis and Exploration of the Implementation System of Mixed Ownership of Scientific and Technological Achievements in Colleges and Universities

The paper identifies key challenges in implementing mixed ownership systems for scientific and technological achievements in colleges and universities and proposes improvements to address these issues.

Identification of a multipotent lung progenitor for lung regeneration

The paper identifies a multipotent lung progenitor that co-expresses endothelial and epithelial markers and contributes to multi-lineage regenerative patches in a transplantation model.

Spatiotemporal heterogeneity and the long-term impact of meteorological , environmental and socio-economic factors of scrub typhus in China from 2012 to 2018

This study analyzes the spatiotemporal patterns of scrub typhus in China from 2012 to 2018, identifying key meteorological, environmental, and socio-economic factors influencing its distribution.

Longitudinal white matter alterations in SIVmac239 infected rhesus monkeys with and without regular cART treatment

This study tracks white matter changes in SIV-infected rhesus monkeys with and without cART, finding early alterations at 4 weeks and varying cART effects over time.

Phase separation and correlated motions in motorized genome

This study simulates the human genome using active forces to show their impact on heterochromatin localization and long-range spatial correlations.

A unique epigenomic landscape defines CD8+ tissue-resident memory T cells

This study identifies distinct epigenetic trajectories in CD8+ T cells during acute infection, revealing how chromatin accessibility changes guide the development of tissue-resident memory T cells versus circulating memory T cells.

Glutamine is essential for overcoming theimmunosuppressive microenvironment in malignant salivary gland tumors

This study shows that dietary glutamine supplementation enhances antitumor immunity by altering the tumor microenvironment in mice with malignant salivary gland tumors.

Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat generated by CRISPR/Cas9

This study generates genetically engineered goats expressing a domain fusion TLR2-4 receptor to enhance autophagy-dependent clearance of Staphylococcus aureus in macrophages.

All-atom molecular dynamics simulations of synaptic vesicle fusion I: a glimpse at the primed state

The paper uses molecular dynamics simulations to study the primed state of synaptic vesicles, revealing a spring-loaded configuration of trans-SNARE complexes bound to synaptotagmin-1 and complexin-1.