B. Yu

Mapping and Engineering Antibody-Antigen Interaction Landscapes for Systematic Affinity Enhancement

The paper introduces a method to map antibody-antigen interactions using SPID platform to enhance affinity prediction and optimize antibody design.

Therapeutic Targeting of TIM-4-L With Engineered T Cells for Acute Myeloid Leukemia

This study identifies TIM-4-L as a novel target for T cell therapy in AML, showing engineered T cells effectively eliminate AML cells in vitro and in vivo.

Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

This study determines the structure of SCARF1 and identifies its ligand recognition mechanism, revealing key residues and shared binding sites for modified LDLs and bacterial teichoic acids.

Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

This study shows leucine reduces cytokine storm syndrome in mice by promoting M2 macrophage polarization via the mTORC1/LXRα signaling pathway.

Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense

The paper identifies the Gabija complex's mechanism of sensing nucleotide depletion and executing DNA cleavage for antiviral defense, showing its unique synergy between GajA and GajB.

Inter-user comparison for quantification of superparamagnetic iron oxides with magnetic particle imaging across two institutions highlights a need for standardized approaches

This study compares MPI quantification across two institutions and users, finding significant differences in signal intensity and SPION quantification due to imager variation.

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

This study investigates chromosome loss in CRISPR-Cas9-engineered T cells and shows a modified manufacturing process reduces it while preserving editing efficacy.

Active maintenance of CD8+ T cell naivety through regulation of global genome architecture

This study shows that transcription factors maintain CD8+ T cell naivety by enforcing a distinct chromatin architecture that remodels upon activation.

A method for rapid nanobody screening with no bias of the library diversity

This paper introduces a method for rapid nanobody screening that preserves library diversity without subcloning or amplification bias, producing functional nanobodies against DR5 and Pfu DNA polymerase.

Vaginal bacteria elicit acute inflammatory response in fallopian tube organoids: a model for pelvic inflammatory disease

The paper uses patient-derived fallopian tube organoids to study inflammatory responses to vaginal bacterial infections, finding species-specific gene upregulation.

Different tissues in the maternal-fetal interface harbor distinct microbiomes showing associations related to their anatomical position or function

The study analyzes microbiome profiles across maternal-fetal tissues, revealing distinct microbial compositions and correlations based on anatomical position.

Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

Rho activation drives luminal collapse and eversion in epithelial acini

This study shows that RhoA activation causes apical-out eversion in epithelial acini by altering mechanical homeostasis and surface tension differences.

Injectable hydrogel embedded with mesenchymal stem cells repairs severe spinal cord injury

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

Root twisting drives halotropism via stress-induced microtubule reorientation

This study identifies the molecular mechanism of root halotropism in Arabidopsis, showing that ABA-mediated microtubule reorientation drives anisotropic cell expansion and root twisting in response to salt stress.

Ubiquitin-like cGAS chain formation by a super enzyme activates anti-phage response

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

Robust Variation in Infant Gut Microbiome Assembly Across a Spectrum of Lifestyles

This study compares infant gut microbiome assembly in Hadza hunter-gatherers and industrialized infants, finding distinct microbial trajectories and functional differences.

Dynamic control of metabolic zonation and liver repair by endothelial cell Wnt2 and Wnt9b revealed by single cell spatial transcriptomics using Molecular Cartography

This study identifies endothelial cell Wnt2 and Wnt9b as key regulators of liver zonation and repair, showing their therapeutic potential in acute liver failure using single-cell spatial transcriptomics.

A magnetic field prevents alcoholic liver disease by reducing oxidative stress

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

The genome of stress tolerant crop wild relativePaspalum vaginatum leads to increased biomassproductivity in the crop Zea mays

This study sequenced Paspalum vaginatum, a stress-tolerant wild relative of maize, and found that inducing trehalose accumulation in maize increases biomass through autophagy.

Augmenting Neutralization breadth against Diverse HIV-1 by increasing the Ab-Ag interface on V2

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

In vivo augmentation of a complex gut bacterial community

The paper improves a synthetic gut microbiota community by adding strains that persist after fecal challenge and removing those that do not, resulting in a more stable model of the human gut microbiome.

RNA-specific condensation promotes auto-regulation of polyQ RNA-binding protein Whi3

The paper shows that Whi3, an RNA-binding protein in Ashbya gossypii, auto-regulates its own transcripts through RNA-specific condensation, affecting nuclear cycling and gene transcription.

IRGM/Irgm1 Aggravates Progression of Atherosclerosis by Inducing Macrophage Apoptosis through the MAPK Signaling Pathway

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

A nucleotide-sensing endonuclease from the Gabija bacterial defense system

This study identifies GajA as a nucleotide-regulated endonuclease from the Gabija bacterial defense system, which is inhibited by NTP and dNTP but activated during phage infection.

CPEB2 m6A Methylation Regulates BTB Permeability via Affecting Splicing Factor SRSF5 Stability

This study identifies a regulatory pathway involving CPEB2 m6A methylation that affects BTB permeability through SRSF5 and P51-ETS1, enhancing drug efficacy in glioma treatment.

Bacterial evolution in high osmolarity environments

This study evolves Escherichia coli in high osmolarity environments and finds that adaptation strategies vary by osmolyte, with specific mutations improving fitness in certain conditions.

Alternative polyadenylation is a determinant of oncogenic Ras function

This study shows that alternative polyadenylation regulates oncogenic Ras function by affecting transcript 3' UTR length in both C. elegans and human cells.

Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China

The paper characterizes the complete genome of a novel coronavirus, WHCV, linked to a respiratory outbreak in Wuhan, finding it closely related to SARS-like bat coronaviruses.

Characterization of the Intestinal Absorption of Morroniside from Cornus officinalis Sieb. et Zucc via a Caco-2 Cell Monolayer Model

This study investigates the intestinal absorption of morroniside using a Caco-2 cell model, finding pH- and temperature-dependent transport and involvement of efflux proteins.