Macrophages induce inflammation by efferocytosis of apoptotic prostate cancer cells via HIF-1α stabilization
V. Mendoza-Reinoso, P. M. Schnepp, D. Y. Baek, J. R. Rubin, E. Schipani, E. T. Keller, L. K. McCauley, H. Roca
This study shows that macrophages clear apoptotic prostate cancer cells via efferocytosis, inducing HIF-1α stabilization and MIF expression, which promotes inflammation and tumor growth in bone.
bioRxiv · Sep 2, 2021 · PreprintCancer Biology