L. Tang

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

This study shows that HSCs produce BMP9/10, which regulate KCs and ECs to maintain liver homeostasis, and their deletion leads to fibrosis and iron overload.

Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair

This study shows that bleomycin-exposed ferrets develop sustained pulmonary fibrosis, restrictive lung physiology, and airway remodeling similar to human IPF.

Curved light sheet microscopy for centimeter-scale cleared tissues imaging

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells

This study compares a novel CFTR potentiator, SK-POT1, to ivacaftor in improving mucociliary clearance in airway epithelial cells exposed to cigarette smoke.

Proteomic Characterization of Intrahepatic Cholangiocarcinoma Identifies Distinct Subgroups and Proteins Associated with Time-To-Recurrence

This study identifies two proteomic subgroups of intrahepatic cholangiocarcinoma with distinct time-to-recurrence rates and biological processes.

A Real-time Multi-Subject Three Dimensional Pose Tracking System for Analyzing Social Behaviors of Non-human Primates

This paper introduces MarmoPose, a real-time 3D pose tracking system for non-human primates, enabling analysis of social behaviors and closed-loop experiments in marmosets.

Vitamin D attenuates diabetic myocardial injury via the Erbb4/ferroptosis axis

This study shows vitamin D reduces diabetic myocardial injury by inhibiting the Erbb4/ferroptosis pathway in both in vivo and in vitro models.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Electron microscopic and crystallographic studies of bacteriophage Sf6 procapsid-like particles assembled from heterologously expressed capsid protein gp5

The paper studies the assembly and structure of bacteriophage Sf6 procapsid-like particles using electron microscopy and crystallography.

Discovery and Engineering of the L-Threonine Aldolase from Neptunomonas Marine for Efficient Synthesis of β-Hydroxy-α-Amino Acids via C-C Formation

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

Temporal colonization of the gut microbiome in neonatal Bos taurus at single nucleotide resolution

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

High-Dimensional Spectral Cytometry Reveals Therapeutically Relevant Immune Subtypes in Gastric Cancer

This study uses high-dimensional spectral cytometry to identify immune subtypes in gastric cancer, finding that certain subtypes correlate with better responses to immunotherapy.

Integrated Drivers of Basal and Acute Immunity in Diverse Human Populations

The paper examines factors influencing immunity across diverse populations, finding ancestry and age significantly affect immune responses and disease severity.

Plastome-based Phylogenomic analyses provide insights into the germplasm resource diversity of Cibotium in China

This study uses plastome data to analyze the genetic diversity and phylogeny of Cibotium species in China, identifying cryptic species and lineage differentiation to aid conservation and breeding efforts.

Mucociliary Clearance Augmenting Drugs Block SARS-Cov-2 Replication in Human Airway Epithelial Cells

This study tests mucoactive drugs that enhance mucociliary clearance and finds three inhibit SARS-CoV-2 replication in human airway epithelial cells by improving ciliary function and redox state.

Alternative Complement Pathway Regulates Thermogenic Fat Function via Adipsin and Adipocyte-derived C3aR1 in a Sex-dependent Fashion

This study shows that the alternative complement pathway, via Adipsin and C3aR1, regulates adipose thermogenesis with sex-dependent effects, impacting energy expenditure and metabolic health.

Rational design of chemically controlled antibodies and protein therapeutics

This study designs and tests small molecule-controlled switchable protein therapeutics by optimizing protein interactions and demonstrating in vitro and in vivo controllability with Venetoclax.

ADOLESCENT EXPOSURE TO LOW-DOSE THC DISRUPTS ENERGY BALANCE AND ADIPOSE ORGAN HOMEOSTASIS IN ADULTHOOD

This study shows that adolescent exposure to low-dose THC leads to metabolic changes in adulthood, including reduced fat mass and adipose dysfunction.

BysR, a LysR-type Pleiotropic Regulator, Controls Production of Occidiofungin by Activating the LuxR-type transcriptional regulator AmbR1 in Burkholderia sp. JP2-270

This paper identifies BysR as a LysR-type regulator that activates ambR1 to control occidiofungin production in Burkholderia sp. JP2-270 and reveals its broader regulatory role in metabolism and motility.

Benzidine Induces Proliferation of UMUC3 Bladder Cancer Cells Through Activation of ERK5 Pathway

This study shows benzidine promotes bladder cancer cell proliferation via the ERK5 pathway by increasing cyclin D1 and PCNA while decreasing p21.

Reprogrammed Schwann cells organize into dynamic tracks that promote pancreatic cancer invasion

This study shows that Schwann cells activated by cancer cells form tracks that promote pancreatic cancer invasion through c-Jun-dependent mechanisms.

Improved pathogen and stress tolerance in tomato mutants of SET domain histone 3 lysine methyltransferases

This study identifies tomato SDG33 and SDG34 histone methyltransferases that regulate stress tolerance by modifying H3K4 and H3K36 methylation and expression of negative regulators.

Dynamic evolution of small signaling peptide compensation in plant stem cell control

The paper investigates how compensation between paralogs evolves in plant stem cell control, showing that a single amino acid change and cis-regulatory variation can reduce compensatory ability in tomato.

ATP and Substrate Binding Regulates Conformational Changes of Human Peroxisomal ABC Transporter ALDP

The paper presents Cryo-EM structures of ABCD1 in different conformational states, revealing how ATP and substrate binding regulate its transport mechanism and disease-related mutations.

Combined use of Candida Utilis and Idesia polycarpa var. Vestita Fruit Improve the Production Performance of Laying Quail

This study evaluates the effect of Idesia polycarpa fruit residues fermented feed additive on laying quail egg production and related performance metrics, finding improved egg production, reduced cholesterol, and enhanced lipid metabolism.

Immunological profiling of COVID-19 patients with pulmonary sequelae

This study examines immune cell profiles in COVID-19 survivors with and without pulmonary sequelae one year post-discharge, identifying immune imbalances linked to residual lung damage.

Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression ofPAK3 via miRNA regulation

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

Transcriptional condensates formed by phase-separated ALOG family proteins control shoot meristem maturation for flowering

This study identifies TFAM3 as a regulator of shoot meristem maturation in plants, showing that ALOG family proteins form transcriptional condensates to control flowering timing and inflorescence architecture.

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

This study shows Tim-3 promotes NF90 ubiquitination and degradation, inhibiting antiviral innate immunity via stress granule formation.

Weight loss response following lifestyle intervention associated with baseline gut metagenomic signature in humans

The paper analyzes weight loss outcomes in response to a lifestyle intervention and identifies baseline gut metagenomic features associated with weight loss in humans.