Author

E. T. Kool

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

L. Xiao· 3 shared L. Fang· 2 shared A. M. Kietrys· 1 shared D. J. Luciano· 1 shared E. J. A. Hubbard· 1 shared H. S. Park· 1 shared J. Burnett· 1 shared J. C. Devlin· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

L. Xiao

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

RNA Infrastructure Profiling Illuminates Transcriptome Structure in Crowded Spaces

L. Xiao, L. Fang, E. T. Kool

The paper introduces RNA infrastructure profiling (RISP) to analyze RNA structure and modifications in crowded cellular environments, showing improved coverage and m6A detection with small acetyl probes.

bioRxiv · Oct 9, 2023Biochemistry

Pervasive Transcriptome Interactions of Protein-Targeted Drugs

L. Fang, W. A. Velema, Y. Lee, L. Xiao, M. G. Mohsen, A. M. Kietrys, E. T. Kool

This study develops a method to assess RNA off-target interactions of protein-targeted drugs and finds they pervasively affect the transcriptome, potentially causing toxicity.

bioRxiv · Jul 18, 2022 · PreprintPharmacology & Toxicology

Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes

M. Venzon, R. Das, D. J. Luciano, J. Burnett, H. S. Park, J. C. Devlin, E. T. Kool, J. G. Belasco, E. J. A. Hubbard, K. Cadwell

The paper identifies microbial byproducts that influence reproductive fitness in both free-living and parasitic nematodes using C. elegans and Trichuris muris.

bioRxiv · Aug 2, 2021Microbiology

Site-specific RNA Functionalization via DNA-induced Structure

L. Xiao, M. Habibian, E. T. Kool

This paper introduces a DNA-directed method to achieve site-specific RNA functionalization by creating localized 2-OH groups for acylimidazole reagent conjugation.

bioRxiv · Aug 6, 2020Biochemistry