K. Cadwell

Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness

This study uses patient-derived intestinal organoids to predict individual clinical responsiveness to tofacitinib in ulcerative colitis by assessing drug sensitivity and MATE1 expression.

Heterozygosity for Crohn's Disease Risk Allele of ATG16L1 Protects against Bacterial Infection

The paper shows that heterozygosity for the ATG16L1 T300A allele protects against Salmonella infection, while homozygosity increases susceptibility.

Temporal Tracking of Plasma Cells in vivo Using J-chain CreERT2 Reporter System.

This study introduces a J-chain CreERT2 reporter system to track plasma cells in vivo, revealing insights into their heterogeneity and longevity.

Sphingosine 1-phosphate receptor 1 inhibition induces a pro-apoptotic signaling cascade in T cells

This study shows that S1PR1 inhibition leads to T cell apoptosis by altering BCL2 family balance and JNK activity, with implications for immune responses in ulcerative colitis.

Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation

The paper characterizes functional properties of helminth-associated Clostridiales bacteria and identifies their role in promoting Treg differentiation and Trichuris egg hatching.

Genetic and Environmental interactions contribute to immune variation in rewilded mice

This study examines how genetics and environment interact to influence immune variation in rewilded mice, finding that genotype drives cytokine responses while genotype-environment interactions shape cellular composition.

Social association predicts immunological similarity in rewilded mice

The paper shows that social association in rewilded mice predicts immunological similarity, with social ties more influential than genetic or parasitic factors.

Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching

This study identifies how bacterial contact triggers polar plug disintegration in whipworm eggs, facilitating larval hatching through chitinase activity rather than bacterial enzymes.

Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization

The paper shows that overproduction of REG3 proteins in IBD flares reduces Enterococcus faecium, worsening inflammation by disrupting microbiota-immune interactions.

Clostridia isolated from helminth-colonized humans promote hatching of Trichuris muris

The paper isolates and characterizes Clostridia from helminth-colonized humans, showing they promote hatching of Trichuris muris eggs.

Gut Microbiome of Helminth Infected Indigenous Malaysians Is Context Dependent

The paper analyzes gut microbiomes of helminth-infected indigenous Malaysians, finding context-dependent effects of helminth infections and albendazole treatment on microbial diversity and composition.

ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection

The paper identifies ACE2-containing exosomes, termed defensosomes, that inhibit SARS-CoV-2 infection by binding and blocking viral entry.

Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes

The paper identifies microbial byproducts that influence reproductive fitness in both free-living and parasitic nematodes using C. elegans and Trichuris muris.

Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection

This study examines inter-individual variability in SARS-CoV-2 infection of intestinal organoids, finding that ACE2 expression levels determine susceptibility and that Omicron variant shows higher infectivity.

Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation.

The paper shows that gut microbiome dysbiosis in COVID-19 patients is linked to increased risk of bacteremia and microbial translocation.

Mapping the evolutionary landscape of Zika virus infection in immunocompromised mice.

This study establishes a ZIKV transmission model in immunocompromised mice to investigate factors influencing viral evolution and DVG production.

Enteric viruses evoke broad host immune responses resembling bacterial microbiome

The paper examines host immune responses to enteric viruses in mice, finding similarities to bacterial microbiome responses and highlighting strain-specific and microbiota-dependent effects.

Transcriptional Atlas of Ileal-Anal Pouch Immune Cells from Ulcerative Colitis Patients

The paper uses single-cell RNA-sequencing to analyze immune cells in ileal pouches and colons of UC patients, identifying specific cell types and their association with inflammation and treatment response.

APOL1 Variant-Expressing Endothelial Cells Exhibit Autophagic Dysfunction and Mitochondrial Stress

This study shows that APOL1 risk variants in endothelial cells impair mitochondrial function, lysosome integrity, and autophagy, with IFN-gamma exacerbating these effects in heterozygous cells.

Housing laboratory mice deficient for Nod2 and Atg16l1 in a natural environment uncovers genetic and environmental contributions to immune variation.

Exposing mice with genetic mutations to a natural environment reveals environmental effects on immune cell populations and genetic effects on cytokine responses.

Altered immunity of laboratory mice in the natural environment is associated with fungal colonization

This study shows that rewilding laboratory mice in an outdoor environment alters their immune system, increasing granulocytes and changing microbiota, but not causing infection from known pathogens.

Vasculature-associated adipose tissue macrophages dynamically adapt to inflammatory and metabolic challenges

The paper identifies vasculature-associated adipose tissue macrophages (VAMs) and shows how they adapt to metabolic and inflammatory challenges in epididymal white adipose tissue.

B cell defects observed in Nod2 knockout mice are a consequence of a Dock2 mutation frequently found in inbred strains

The paper identifies a Dock2 mutation in Nod2-/- mice that causes B cell defects, independent of Nod2 deletion, and shows the mutation is common in inbred strains.