Pharmacology & ToxicologybioRxivPreprint
Pervasive Transcriptome Interactions of Protein-Targeted Drugs
L. Fang, W. A. Velema, Y. Lee…·E. T. Kool
This study develops a method to assess RNA off-target interactions of protein-targeted drugs and finds they pervasively affect the transcriptome, potentially causing toxicity.
DOI 10.1101/2022.07.18.500496