J. C. Devlin

A role for BCL6 in maintaining CX3CR1+ CD4+ T cells during helminth infection

The paper identifies BCL6's role in maintaining CX3CR1+ CD4+ T cells during helminth infections through fate-mapping and single-cell RNA-sequencing.

Single-cell analysis of CX3CR1+ cells reveal a pathogenic role for BIRC5+ myeloid proliferating cells driven by Staphylococcus aureus leukotoxins

The paper identifies BIRC5+ myeloid cells as pathogenic during S. aureus infection using scRNA-seq and genetic fate mapping.

Clostridia isolated from helminth-colonized humans promote hatching of Trichuris muris

The paper isolates and characterizes Clostridia from helminth-colonized humans, showing they promote hatching of Trichuris muris eggs.

Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes

The paper identifies microbial byproducts that influence reproductive fitness in both free-living and parasitic nematodes using C. elegans and Trichuris muris.

A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19

This study compares the antiviral efficacy of PF-00835231, GC-376, and remdesivir in human airway models, showing PF-00835231 is at least as potent as the others and not affected by P-glycoprotein efflux.

Transcriptional Atlas of Ileal-Anal Pouch Immune Cells from Ulcerative Colitis Patients

The paper uses single-cell RNA-sequencing to analyze immune cells in ileal pouches and colons of UC patients, identifying specific cell types and their association with inflammation and treatment response.

Housing laboratory mice deficient for Nod2 and Atg16l1 in a natural environment uncovers genetic and environmental contributions to immune variation.

Exposing mice with genetic mutations to a natural environment reveals environmental effects on immune cell populations and genetic effects on cytokine responses.

Altered immunity of laboratory mice in the natural environment is associated with fungal colonization

This study shows that rewilding laboratory mice in an outdoor environment alters their immune system, increasing granulocytes and changing microbiota, but not causing infection from known pathogens.

Distinct features of human myeloid cell cytokine response profiles identify neutrophil activation by cytokines as a prognostic feature during tuberculosis and cancer

The paper identifies neutrophil cytokine response profiles as prognostic markers in tuberculosis and cancer by analyzing myeloid cell transcriptional responses to various cytokines.

Integrating single-cell RNA-Seq with spatial transcriptomics in pancreatic ductal adenocarcinoma using multimodal intersection analysis

This study integrates single-cell RNA-Seq and spatial transcriptomics data from pancreatic cancer tissue to map cell type spatial distributions and infer tissue architecture.