Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade
M. Mahmood, E. M. Liu, A. L. Shergold, E. Tolla, J. Tait-Mulder, A. H. Uribe, E. Shokry, A. L. Young, S. Lilla, M. Kim, T. Park, J. L. Manchon, C. Rodriguez-Antona, R. C. Walters, R. J. Springett, , P. A. Gammage
This study shows that mitochondrial DNA mutations in complex I genes drive aerobic glycolysis, enhancing immune checkpoint blockade response in tumors.
bioRxiv · Mar 21, 2023 · PreprintCancer Biology