Cell BiologybioRxivPreprint
GPCR binding and JNK3 activation by arrestin-3 have different structural requirements
C. Zheng, L. D. Weinstein, K. K. Nguyen…·V. V. Gurevich
This study shows that GPCR binding and JNK3 activation by arrestin-3 require distinct structural features, with Lys-295 playing a key role in GPCR binding but not in JNK3 activation.
DOI 10.1101/2023.05.01.538990