C. Zheng

A Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis

This study identifies GLP-1(32-36) as a therapeutic agent that rescues diabetic ischemic lower limbs by enhancing glycolysis and EPC function via GLP-1R-dependent mechanisms.

Editing of endogenous tubulins reveals varying effects of tubulin posttranslational modifications on axonal growth and regeneration

This study edits endogenous tubulin to assess how different posttranslational modifications affect axonal growth and regeneration in C. elegans neurons.

Beige adipose tissue-derived extracellular vesicles: a potent metabolic regulator and a novel remedy for nonalcoholic fatty liver disease

This study isolates and characterizes beige adipose tissue-derived extracellular vesicles (BeEVs) and shows they improve metabolic dysfunction in a nonalcoholic fatty liver disease model.

In vitro antimicrobial mechanism of diacerein and potential to reverse MRSE resistance to β-lactams

This study investigates diacerein's antimicrobial mechanism against MRSE and shows it can reverse β-lactam resistance by affecting efflux systems and inducing cell lysis.

Casein kinase II promotes piRNA production through direct phosphorylation of USTC component TOFU-4

This study identifies casein kinase II (CK2) as a regulator of piRNA production by phosphorylating TOFU-4, a component of the USTC complex, and shows its role in aging-related piRNA silencing defects.

Ninein domains required for its localization, association with partners dynein and ensconsin, and microtubule organization

This study identifies Nin domains critical for its localization, interactions with dynein and ensconsin, and microtubule organization in Drosophila.

GPCR binding and JNK3 activation by arrestin-3 have different structural requirements

This study shows that GPCR binding and JNK3 activation by arrestin-3 require distinct structural features, with Lys-295 playing a key role in GPCR binding but not in JNK3 activation.

Computational ranking-assisted identification of Plexin-B2 in homotypic and heterotypic clustering of circulating tumor cells in breast cancer metastasis

This study identifies Plexin-B2 as a driver of homotypic and heterotypic CTC clusters in breast cancer metastasis, with high expression linked to poor prognosis and therapeutic potential.

Adaptive-learning physics-aware light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

RNA Sensing and Innate Immunity Constitutes a Barrier for Interspecies Chimerism

This study identifies RNA sensing and innate immunity in host embryos as a barrier to interspecies chimerism and shows that modifying host embryos can enhance human cell survival in chimeric embryos.

Novel Small Molecular Compound AE-848 Showed Potent Inhibitory Activity Against Human Hepatoblastoma Cells

This study investigates the anti-hepatoblastoma effects of the compound AE-848, showing it inhibits cell proliferation, induces apoptosis, and reduces tumor growth in vivo.

GRHL2 enhances phosphorylated estrogen receptor DNA-binding and regulates ER-mediated transcriptional activation and repression

This study shows GRHL2 enhances pS118-ER DNA-binding and regulates ER-mediated transcriptional activation and repression in breast cancer cells.

Human Lung-resident Mucosal-Associated Invariant T cells are Abundant, Express Antimicrobial Proteins, and are Cytokine Responsive

The paper identifies and characterizes lung-resident MAIT cells, showing they express antimicrobial proteins and are cytokine responsive.

Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

Dynamic evolution of recently duplicated genes in Caenorhabditis elegans

This study examines the evolutionary dynamics of recently duplicated genes in C. elegans, finding they show rapid turnover, high diversity, and selection signals but are rarely essential.

A snapshot of the root phenotyping landscape in 2021

This paper surveys the current state of root phenotyping, identifying key trends, challenges, and needs in the field.

Regulation of drought tolerance in Arabidopsis involves PLATZ4-mediated transcriptional suppression of PIP2;8

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

The cardiac STAT3 intercalated disc specific expression in tail suspension rat

This study examines right ventricle remodeling in tail-suspended rats under microgravity simulation, finding STAT3 accumulation and gap junction remodeling without significant hypertrophy.

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

This paper improves prime editors for genome editing in adult mice, enabling pathogenic mutation correction and cancer modeling.

An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

β-Amyloid peptides tailor switching behaviors of Donor-Acceptor Stenhouse Adducts

The paper shows that β-Amyloid peptides modulate the switching behavior of donor-acceptor Stenhouse adducts, reducing molecular switching rates and inhibiting aggregation.

Large genetic diversity and strong positive selection in F-box and GPCR genes among the wild isolates of Caenorhabditis elegans

This study identifies large genetic diversity and strong positive selection in F-box and chemosory GPCR genes across 330 C. elegans wild isolates, with significant divergence in non-Hawaiian populations.

Accurate Diagnosis of Colorectal Cancer Based on Histopathology Images Using Artificial Intelligence

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy

This study shows artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression by enhancing autophagy and modulating NF-κB activity.

WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.

This study identifies WDR90 as a centriolar microtubule wall protein essential for maintaining centriole structure in human and Chlamydomonas cells.

A perinuclear microtubule-organizing center controls nuclear positioning and basement membrane secretion

This paper identifies a novel perinuclear microtubule-organizing center in Drosophila fat body cells that controls nuclear positioning and basement membrane secretion through specific protein interactions and MT assembly mechanisms.

The virus integrations in gut microbes associated with dysbiosis of microbial community in tumorigenesis of colorectal carcinoma

This study identifies viral genetic integrations in gut microbes associated with microbial dysbiosis in colorectal carcinoma tumorigenesis.

Predicting cancer origins with a DNA methylation-based deep neural network model

This paper develops a DNA methylation-based deep neural network model to predict cancer origins with high accuracy across multiple datasets and cancer types.

Lyb-2-4, a unique genomic region of hypervirulent carbapenem-resistant Acinetobacter baumannii

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.