Pharmacology & ToxicologybioRxiv
A 3D brain unit model to further improve prediction of local drug distribution within the brain
E. Vendel, V. Rottschäfer, E. C. M. de Lange
This paper develops a 3D brain unit model to quantify how factors like blood flow, BBB transport, and drug binding affect local drug concentrations in brain extracellular fluid.
DOI 10.1371/journal.pone.0238397