Author

E. W. Lake

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Biophysics· 1

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Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

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A. Thompson· 1 shared D. D. Thomas· 1 shared E. F. Ruff· 1 shared J. D. Chodera· 1 shared J. M. Behr· 1 shared J. M. Muretta· 1 shared N. M. Levinson· 1 shared S. Cyphers· 1 shared

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1 shared paperBiophysics

A. Thompson

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1 paper

Recent·Most cited

BiophysicsbioRxivOct 18, 2017

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

E. F. Ruff, J. M. Muretta, A. Thompson…·N. M. Levinson

This study shows that phosphorylation of Aurora A's activation loop activates the kinase without shifting the DFG-In state population, and that a DFG-Out subpopulation is important for optimized substrate binding kinetics.

DOI 10.7554/elife.32766

mechanistic / dynamical modelexperimental assay

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