A. Thompson

Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family

This study characterizes the structure and function of the minimal orthomyxovirus-like polymerase from Tilapia Lake Virus, revealing its active domains and inactive features.

Decoupled evolution of the Sex Peptide gene family and Sex Peptide Receptor in Drosophilidae

The paper traces the evolutionary history of the Sex Peptide gene family and its receptor in 264 Drosophila species, finding divergent trajectories and weak coevolutionary signals.

Drug discovery for heart failure targeting myosin-binding protein C

This study identifies small molecules that modulate cMyBP-C interactions with actin or myosin, aiming to develop therapies for heart failure.

The Primacy of Temporal Dynamics in Driving Spatial Self-organization of Soil Redox Patterns

This study identifies two coupled scale-dependent feedbacks and environmental variability as key drivers of regular redox patterns in upland soils.

Deep learning and likelihood approaches for viral phylogeography converge on the same answers whether the inference model is right or wrong

This paper compares deep learning and likelihood methods for viral phylogeography, finding they produce similar results and robustness to model errors, with deep learning being significantly faster.

Some like it hotter: differential thermal preferences among lizard color morphs

This study finds that orange morphs of the Aegean wall lizard prefer cooler temperatures than white and yellow morphs, suggesting thermal preferences contribute to color polymorphism maintenance.

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

The paper engineers nanobody interfaces to improve crystal reliability and diversity, resulting in better diffraction and multiple polymorphs.

The wild life of ticks: using passive surveillance to determine the distribution and wildlife host range of ticks and the exotic Haemaphysalis longicornis, 2010-2021

This study used passive wildlife surveillance to collect tick data across the eastern U.S., identifying the distribution of exotic H. longicornis and other tick species, and generating new county reports for several important tick species.

Evolution and development of male-specific leg brushes in Drosophilidae

The paper investigates the evolution and development of male-specific sex brushes in Drosophilidae, finding similar developmental mechanisms across lineages despite uncertain phylogenetic origins.

Microbial metabolite butyrate-prodrug polymeric micelles demonstrate therapeutic efficacy in pre-clinical models of food allergy and colitis

The paper develops butyrate-prodrug polymeric micelles that restore gut barrier function and reduce inflammation in pre-clinical models of food allergy and colitis.

Secondary reversion to sexual monomorphism associated with tissue-specific loss of doublesex expression

The paper examines the loss of a male-specific sex comb in a Drosophilidae species, linking it to a secondary loss of doublesex (dsx) expression, and discusses implications for the evolution of sexual dimorphism.

Cumulative impacts across Australia's Great Barrier Reef: A mechanistic evaluation

The paper evaluates cumulative impacts on the Great Barrier Reef by simulating coral demographics and stressor effects across 2,300 km of reef, finding coral cover declined by one third from 2008-2020 with bleaching as the primary driver.

Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster

This study examines natural variation in maternal and zygotic mRNA levels in Drosophila melanogaster across populations, finding greater conservation of maternal transcripts and higher evolutionary rate in zygotic transcripts.

A two-year study on the phenology, host and habitat associations, and pathogens of Haemaphysalis longicornis in Virginia, U.S.A.

This study tracks Haemaphysalis longicornis phenology, host associations, and pathogens in Virginia over two years, finding year-round nymphal activity and novel host and pathogen associations.

Understanding Lactobacillus paracasei and Streptococcus oralis biofilm interactions through agent-based modeling

This paper uses agent-based modeling and experiments to study interactions between Lactobacillus paracasei and Streptococcus oralis in biofilms, finding that L. paracasei may inhibit S. oralis growth.

Root carbon interaction with soil minerals is dynamic, leaving a legacy of microbially-derived residues

The paper investigates how plant-derived carbon interacts with soil minerals and microbial activity, finding that rhizosphere conditions shape the chemistry of mineral-associated organic matter.

Highly contiguous assemblies of 101 drosophilid genomes

The paper presents high-quality genome assemblies for 101 drosophilid lines using Oxford Nanopore sequencing, achieving high contig N50 and BUSCO completeness.

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML

This study shows that chronic STAG2 loss alters chromatin structure and deregulates transcription in AML, affecting HOXA and MAPK pathways.

Mapping and dynamics of regulatory DNA in maturing seeds

The paper maps regulatory DNA dynamics in Arabidopsis thaliana seeds and finds novel regulatory elements that are more developmentally influenced than environmental factors.

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

This study shows that phosphorylation of Aurora A's activation loop activates the kinase without shifting the DFG-In state population, and that a DFG-Out subpopulation is important for optimized substrate binding kinetics.

Regulatory DNA in A. thaliana can tolerate high levels of sequence divergence

The paper examines regulatory DNA variation in Arabidopsis thaliana, finding that chromatin accessibility differences often correlate with gene expression changes despite limited sequence variation.