Author

E. Westra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:development & morphogenesis· 2 Research Focus:ecology & biodiversity· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

E. Pursey· 3 shared S. Gandon· 3 shared S. van Houte· 3 shared A. Biswas· 2 shared A. Chevallereau· 2 shared A. Maestri· 2 shared S. Meaden· 2 shared A. Buckling· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersEvolutionary Biology

E. Pursey

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Eco-evolutionary feedbacks shape the evolution of constitutive and inducible defences

B. Watson, E. Pursey, S. Gandon, E. Westra

The paper shows that the initial resistance mechanism in bacteria during an epidemic strongly influences the evolution of constitutive and inducible defenses, with ecological factors shaping long-term outcomes.

bioRxiv · Apr 14, 2023 · PreprintEvolutionary Biology

Bacterial defences interact synergistically by disrupting phage cooperation

A. Maestri, E. Pursey, C. Chong, B. J. Pons, S. Gandon, R. Custodio, M. Chisnall, A. Grasso, S. Paterson, K. S. Baker, S. van Houte, A. Chevallereau, E. Westra

This study identifies a novel bacterial defence system, MADS, which synergizes with CRISPR-Cas to protect against phages with anti-CRISPR genes by disrupting phage cooperation.

bioRxiv · Mar 30, 2023 · PreprintMicrobiology

How important is CRISPR-Cas for protecting natural populations of bacteria against infections by mobile genetic elements??

E. Westra, B. R. Levin

This paper explores the ecological and evolutionary role of CRISPR-Cas systems in bacteria and archaea using simulation models and literature review.

bioRxiv · Feb 5, 2020Evolutionary Biology

Transient CRISPR immunity leads to coexistence with phages

S. Meaden, L. Capria, E. Alseth, A. Biswas, L. Lenzi, A. Buckling, S. van Houte, E. Westra

This study shows that CRISPR-based immunity in bacteria is transient, leading to stable coexistence with phages due to fitness costs and loss of spacers.

bioRxiv · Dec 19, 2019 · PreprintMicrobiology

Bacterial biodiversity drives the evolution of CRISPR-based phage resistance in Pseudomonas aeruginosa

E. O. Alseth, E. Pursey, A. Lujan, I. McLeod, C. Rollie, E. Westra

This study shows that bacterial biodiversity promotes CRISPR-based phage resistance evolution in Pseudomonas aeruginosa by increasing fitness trade-offs associated with receptor mutation.

bioRxiv · Mar 24, 2019Evolutionary Biology

Exploitation of the cooperative behaviours of anti-CRISPR phages

A. Chevallereau, S. Meaden, O. Fradet, M. Landsberger, A. Maestri, A. Biswas, S. Gandon, S. van Houte, E. Westra

This study shows Acr-negative phages benefit from Acr-positive phages by exploiting their immunosuppressive effects, with stronger Acr proteins providing greater fitness advantages.

bioRxiv · Mar 12, 2019Microbiology