Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor
S. De Gieter, E. Wijckmans, D. Pasini, C. Ulens, R. G. Efremov
This study presents the first cryo-EM structure of an invertebrate nACh-like receptor, revealing conformational changes induced by sterol derivative binding and unique structural features.
bioRxiv · Jan 6, 2023Biochemistry