BiochemistrybioRxiv
Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor
S. De Gieter, E. Wijckmans, D. Pasini…·R. G. Efremov
This study presents the first cryo-EM structure of an invertebrate nACh-like receptor, revealing conformational changes induced by sterol derivative binding and unique structural features.
DOI 10.7554/elife.86029