Author

C. Ulens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

D. Pasini· 3 shared A. Mehregan· 2 shared E. Lindahl· 2 shared R. J. Howard· 2 shared A. Elbahnsi· 1 shared A. H. Laustsen· 1 shared A. N. Hayward· 1 shared A. Sridhar· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

D. Pasini

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules

R. N. Patel, R. H. Clare, L. Ledsgaard, M. Nys, J. Kool, A. H. Laustsen, C. Ulens, N. R. Casewell

This paper develops an in vitro assay to screen for venom neurotoxin activity on muscle-type nAChR and identify toxin-inhibitory molecules, showing robust assay performance across 96-well plates.

bioRxiv · Apr 28, 2023 · PreprintPharmacology & Toxicology

Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

S. De Gieter, E. Wijckmans, D. Pasini, C. Ulens, R. G. Efremov

This study presents the first cryo-EM structure of an invertebrate nACh-like receptor, revealing conformational changes induced by sterol derivative binding and unique structural features.

bioRxiv · Jan 6, 2023Biochemistry

Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycan

M. J. Anderson, A. N. Hayward, A. T. Smiley, K. Shi, M. R. Pawlak, E. J. Aird, E. Grant, L. Greenberg, H. Aihara, C. Ulens, R. L. Evans, W. R. Gordon

This study identifies a unique mechanism by which dystroglycan is cleaved by MMPs, showing that structural changes disrupt DGC integrity and contribute to disease.

bioRxiv · Apr 4, 2022Biochemistry

Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium

A. Mehregan, S. Perez-Conesa, Y. Zhuang, A. Elbahnsi, D. Pasini, E. Lindahl, R. J. Howard, C. Ulens, L. Delemotte

This study investigates the SARS-CoV-2 E protein's effects on membrane curvature and intracellular calcium, using experimental and computational methods.

bioRxiv · May 28, 2021Biophysics

A cationic lipid site at the outward transmembrane face of a pentameric ligand-gated ion channel

A. Sridhar, S. C. R. Lummis, D. Pasini, A. Mehregan, M. Brams, K. Kambara, D. Bertrand, E. Lindahl, R. J. Howard, C. Ulens

This study identifies a cationic lipid binding site on the outward face of the ELIC pLGIC, supported by simulations and mutagenesis, with implications for lipid modulation and drug design.

bioRxiv · Mar 24, 2021 · PreprintBiophysics