This study challenges the notion of RAS as a tumor suppressor by showing that data supporting this role are consistent with known RAS biology using a mathematical model.

DOI 10.1101/153692

statistical model

𝕏 PostBluesky

PathologybioRxivPreprintJun 21, 2017

A computational panel of pathological RAS mutants with implications for personalized medicine and genetic medicine

Chelsey Kenney, Edward C. Stites

This paper develops a computational model of 16 oncogenic RAS mutants and 14 RASopathy mutants to analyze their signaling strengths and implications for personalized medicine.

DOI 10.1101/153726

statistical model

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMay 21, 2014

Differences in sensitivity to EGFR inhibitors could be explained by described biochemical differences between oncogenic Ras mutants

Edward C. Stites

The paper uses a mathematical model to show that biochemical differences between KRAS mutants explain differential sensitivity to EGFR inhibitors.

DOI 10.1101/005397

humanmechanistic / dynamical model

𝕏 PostBluesky