GeneticsProceedings of the National Academy of SciencesPeer-reviewed
Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs
Sara Bizzotto, Maya Talukdar, Edward Stronge…·Christopher A. Walsh
This study uses snRNA-seq and a new method called GO-TEN to analyze mosaic genetic variants in focal cortical dysplasia, revealing cell-autonomous and non-cell-autonomous transcriptional changes associated with epilepsy.