Cancer BiologyNature CommunicationsPeer-reviewed
Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of ER+ breast cancer brain metastases in young and aged hosts
Morgan S. Fox, Jenny A. Jaramillo-Gómez, Ricaurte Alejandro Marquez-Ortíz…·Diana M. Cittelly
This study shows FGFR1 amplification drives ER+ breast cancer brain metastasis in young and aged mice via FGF2 and NCAM1 interactions, with FGFR inhibitors effective in early stages.
DOI 10.1038/s41467-026-73726-5