Synthetic BiologyScience AdvancesPeer-reviewed
Synthetic genetic circuits to uncover and enforce the OCT4 trajectories of successful reprogramming of human fibroblasts
Katherine Ilia, Nika Shakiba, Trevor Bingham…·Thorsten M. Schlaeger
The paper identifies OCT4 trajectories critical for reprogramming human fibroblasts to iPSCs and develops a synthetic genetic circuit to enforce these trajectories, improving reprogramming efficiency.
23 citations