Katherine Ilia

This study reveals analog epigenetic memory through graded DNA methylation, showing its temporal stability and role in gene expression regulation.

The paper identifies OCT4 trajectories critical for reprogramming human fibroblasts to iPSCs and develops a synthetic genetic circuit to enforce these trajectories, improving reprogramming efficiency.

This paper develops synthetic phosphorylation-based signaling networks in mammalian cells that are tunable, precise, and robust to perturbations.