Evolutionary BiologymBioPeer-reviewed
Density-dependent feedback limits the spread of a beta-lactamase mutant: experimental observations and population dynamic model
Philip Ruelens, Eline de Ridder, J. Arjan G. M. de Visser, Meike T. Wortel
The paper investigates how cell density and antibiotic concentration affect the spread of beta-lactamase mutants, showing that density determines whether a resistant strain outcompetes or coexists with a susceptible strain.