Cancer BiologybioRxivPreprint
DUSP6 is transcriptionally upregulated by activated ALK and cooperates with ALK signaling to reduce lorlatinib sensitivity in neuroblastoma cells
Elliott M. Thompson, Vruti Patel, Christina Karapouliou…·Andrew W. Stoker
This study identifies DUSP6 as a novel effector of ALK signaling in neuroblastoma, showing it enhances ALK-driven proliferation and reduces sensitivity to ALK inhibitors.
DOI 10.64898/2026.06.07.730727