Adeno-associated virus (AAV)-TBX18 does not generate biological pacemaker activity, unlike AAV-Hcn2
Jianan Wang, Mathilde R. Rivaud, Mischa Klerk, Arnie Boender, Ruud N. Visser, Rinske Sparrius, Hee Young Lee, Karel van Duijvenboden, Huiling Zhou, Yuting Yang, Emiel Kramer, Kyung Ho Park, Larry C. Park, Silke Schrödel, Christian Thirion, , Gerard J.J. Boink
This study compares AAV-TBX18 and AAV-Hcn2 in generating biological pacemaker activity, finding TBX18 ineffective while Hcn2 induces robust ectopic pacing.
Journal of Clinical Investigation · Jun 11, 2026Peer-reviewedPhysiology