Emily E. Burke

SPEAQeasy provides a user-friendly, scalable RNA-seq pipeline that simplifies data processing and connects to R/Bioconductor tools for downstream analysis.

The paper examines the developmental expression of genes related to voltage-gated cation channels and their association with psychiatric disorders, finding that gene expression patterns vary with age and disorder type.

The paper uses hiPSC transcriptomics to study neuronal differentiation and maturation across multiple conditions and develops a tool to estimate neuronal maturity.

This study characterizes DNA methylation changes in human neurons across development, identifies distinct methylation patterns, and links them to heritable brain-related phenotypes.

This study evaluates biases in small RNA sequencing methods, showing that UMIs improve accuracy and highlighting limitations in current miRNA and isomiR quantification.

The paper identifies regional differences in gene expression and regulation in hippocampus and dorsolateral prefrontal cortex across development and in schizophrenia using RNA-seq data from 900 samples.

The paper characterizes nuclear and cytoplasmic transcriptomes in human cortex development and finds increased nuclear retention in mature brain, linked to psychiatric disease gene regulation.

The paper compares mouse models of syndromic ASD with human ASD brain data to identify shared myelination and axon development disruptions across both syndromic and idiopathic ASD.