NeuroscienceScientific ReportsPeer-reviewed
Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington’s disease
Robert M. Bragg, Sydney R. Coffey, Rory M. Weston…·Jeffrey B. Carroll
This study shows that B6.HttQ111/+ mice exhibit early transcriptional and proteostatic deficits before synapse loss and neurodegeneration in HD.
21 citations