The atypical IκB factor IκBδ enhances CD8 T cell accumulation and effector functions in solid tumors
Barsha Dash, Xiaocui He, Arlet Lara-Custodio, Leo J. Arteaga-Vazquez, Yue Zhao, Hannah Drum, Osamu Ikeda, Eric Johnson, Yuntian Zhu, Chen Zhang, Srikanth Battu, Edahí González‐Avalos, Anjana Rao, Patrick G. Hogan
This study identifies IκBδ as a factor that enhances CD8 T cell accumulation and effector functions in solid tumors by overcoming constraints on T cell survival and cytotoxic capacity.
bioRxiv · Jun 19, 2026 · PreprintImmunology