Eric Schadt

Elective genomic sequencing for adults in research, clinical and commercial contexts

The paper examines motivations and outcomes of elective genomic sequencing across research, clinical, and commercial contexts, finding most participants found results medically important but few shared them with healthcare providers.

Resilience to dominant genetic disease in the healthy elderly

The paper screens healthy elderly individuals to identify those resilient to genetic diseases despite high genetic risk, finding 141 individuals without associated disease despite pathogenic variants.

Molecular Networks and Key Regulators of the Dysregulated Neuronal System in Alzheimer’s Disease

This study identifies molecular networks and key regulators in Alzheimer’s Disease using integrative genomics and experimental validation.

Unperturbed Expression Bias of Imprinted Genes in Schizophrenia

The paper analyzes allelic expression bias in schizophrenia using RNA-seq data to assess imprinted gene expression and its relationship with age, ancestry, and disease.

Extensive sequencing of seven human genomes to characterize benchmark reference materials

The paper presents extensive sequencing data from seven human genomes to serve as benchmark reference materials for improving sequencing technologies and variant calling.

Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes

This paper introduces a novel SMRT sequencing framework for single molecule-level detection of DNA methylation and epigenetic phasing in bacterial methylomes, revealing improved resolution and distinct epigenetic heterogeneity.