NeurosciencebioRxivPreprint
A role for the spinal cord cholinergic neuron circadian clock in RNA metabolism and mediating ALS disease phenotypes
Sharon B. Tam, Nathan J. Waldeck, Matthew Wright…·Robert Gordon Kalb
The paper shows that the circadian clock in spinal cord cholinergic neurons affects RNA metabolism and contributes to ALS disease phenotypes through rhythmic gene expression and alternative splicing.
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