Author

Estelle Bergiron

Lyon 1 Université

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Biology Disciplines

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Bioinformatics· 1

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Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1 Approach:transformer / foundation model· 1

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Bastien BoussauiD· 1 shared Julien BarnieriD· 1 shared Luca NesterenkoiD· 1 shared Philippe VeberiD· 1 shared

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Bastien BoussauORCID

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BioinformaticsbioRxivPreprintJul 1, 2025

Characterization of selective pressures acting on protein sites with Deep Learning

Estelle Bergiron, Luca Nesterenko, Julien Barnier…·Bastien Boussau

This paper develops a deep learning model to identify selective pressures on protein sites, showing it outperforms likelihood-based methods on similar data but is less effective on divergent datasets.

DOI 10.1101/2025.07.01.662578

protein sequencedeep learning

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