NeurosciencebioRxivPreprint
Transferrin receptor-binding blood-brain barrier shuttle enhances brain delivery and efficacy of a therapeutic anti-Abeta antibody
Marta Ramos Vega, Henrik H. Hansen, Camilla Stampe Jensen…·Jacob Hecksher‐Sørensen
This study shows that fusing an anti-Aβ antibody to a TfR1-binding Fab fragment enhances brain delivery and plaque clearance while reducing adverse effects in APP/PS1 mice.
DOI 10.1101/2025.02.14.638216