A Critical Role of Hepatic GABA in The Metabolic Dysfunction and Hyperphagia of Obesity
C. E. Geisler, S. Ghimire, S. M. Bruggink, K. E. Miller, S. N. Weninger, J. M. Kronenfeld, J. Yoshino, S. Klein, F. A. Duca, B. J. Renquist
This study shows that inhibiting hepatic GABA production in obese mice reduces hyperinsulinemia, improves glucose tolerance, and decreases food intake, suggesting a role for hepatic GABA in obesity-related metabolic dysfunction.
bioRxiv · Apr 2, 2020Physiology